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KMID : 0378119920190010119
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Chungnam Medical Journal
1992 Volume.19 No. 1 p.119 ~ p.126
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A Clinical Study of Ga-67Citrate Scan in Primary or Secondary Nephritis
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Abstract
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Ga-67 citrate scan has been requested for detection or follow-up of inflammatory or neoplastic disease.
Visualization of Ga-67 citrate in the kidneys at 48 and 72 hr post injection is usually interpreted as evidence of renal pathology. But precise mechanisms of abnormal Ga-67 uptake in kidneys were unknown.
We undertook a study to determine the value of Ga-67 citrate imaging of the kidneys in 68 patients with primary or secondary nephropathy confirmed by renal biopsy and 66 control patients without renal disease. Renal uptake in 48 to 72 hr images
was
graded as follows : Grade 0=background activity : 1=faint uptake greater than background ; 2=definit uptake, but less than lumbar vertebrae ; 3=same uptake as lumbar vertebrae, but less than liver ; 4=same or higher uptake than liver.
@ES The results were as follows.
@EN 1) 42 of 68 (62%) patients with noninfectious nephritis showed grade 2 or higher Ga-67 renal uptake but only 10 percent of control patients showed similar uptake.
2) In 14 patients with systemic lupus erythematosus, 8 of 9 (89%) patients with lupus nephritis exhibited marked renal uptake.
3) 34 of 41 patients (84%) with combined nephrotic syndrome showed Grade 2 or higher renal uptake.
In conclusion, we thought that because the uptake of renal Ga-67 in patients with combined nephrotic syndrome was higher than nonnephrotic patients, the mechanism of renal Ga-67 uptake might be relate to the pathogenesis of nephrotic syndrome. In
systemic lupus erythematosus, Ga-67 citrate scan is useful in predicting renal involvement.
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